Robert Downey Jr.'s casting in "Two and a Half Men" could be considered coincidental, mainly because Adrian wasn't interested in having Charlie Sheen star in the TV series. Having a fair understanding of the popular series from a previous life, he knew that Charlie Sheen's various misdeeds had caused great trouble for the crew. Although Sheen had brought the character to life and the production team had been quite tolerant, eventually he was unceremoniously ousted. But that happened after several seasons, by which time the character had become deeply beloved. Even though everyone agreed that it was time for a cast change, the inevitable decline in viewership was considerable.
So, when Adrian decided to nip the problem in the bud, his first move post-production was to exclude Charlie Sheen. However, there still needed to be a suitable actor to take on the lead role, right? That's where Robert Downey Jr. entered the picture.