But the issue arose during the animal experiment phase: the mouse model showed that although the new vector had an inhibitory effect on pancreatic tumors, it unexpectedly caused mild inflammatory reactions in the liver and kidneys.
"Off-target toxicity." Song Zimo gazed at the pathology slices, brows furrowed, "Although it's not severe, it does exist. The vector may have recognized similar receptors with low expression levels in normal tissues."
Tang Shun called up the receptor expression profile data: "This receptor is widely expressed during the fetal period, with only trace expression in a few tissues in adults. But our vector has too high an affinity, capturing even the trace expressions."
Yang Ping stood in front of the whiteboard, which was filled with signal pathways and gene sequences. He had been working continuously for a whole day, yet his mind remained clear.
