Not only because it is difficult for Him to find followers who share His interests, but also because humans simply cannot communicate with Him. His voice drives them insane, causing them to act irrationally, even self-harm, and this is true for His most devout followers as well.
Ethan mentioned the Third Epoch during his conversation.
Bloody arts, Scarlet Dynasty.
That was the first time He attempted to promote His own interests. He endowed those humans with more powerful bodies, nearly eternal life. To achieve these, He prepared for a long time and conducted countless experiments to maintain 'life' in its most stable state.
However, humans were not interested.
They tried every means to combat the Scarlet Plague, rejecting His gifts, until human coalition forces broke through the city of the Red King. A skilled assassination team succeeded, and that marked the end of the Scarlet Dynasty.